Flights from Des Moines with American Airlines

Popular flights from Des Moines

$
Travel Class

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

With an expansive network of destinations, your world is a flight away

To search for a great fare, start by selecting your departure city. Looking to book using miles? Try our miles finder map.

Find deals on flights from Des Moines

$
Travel Class

Des Moines (DSM)to

Phoenix (PHX)
02/25/25 - 03/05/25

Round trip

I

Economy

from
$197*
Updated: 16 hours ago

Des Moines (DSM)to

Dallas (DFW)
01/18/25 - 01/25/25

Round trip

I

Economy

from
$275*
Updated: 7 hours ago

Des Moines (DSM)to

Orlando (MCO)
01/14/25 - 01/21/25

Round trip

I

Economy

from
$284*
Updated: 8 hours ago

Des Moines (DSM)to

New York (LGA)
01/18/25 - 01/25/25

Round trip

I

Economy

from
$279*
Updated: 17 minutes ago

Des Moines (DSM)to

Miami (MIA)
01/21/25 - 01/28/25

Round trip

I

Economy

from
$274*
Updated: 42 minutes ago

Des Moines (DSM)to

San Juan (SJU)
01/22/25 - 01/29/25

Round trip

I

Economy

from
$336*
Updated: 1 hour ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.