Flights from Des Moines to Myrtle Beach with American Airlines

Recent searches for flights from Des Moines to Myrtle Beach

Apr 2025
From$308*
Updated: 6 hours ago
Round tripIEconomy
$271
$725
Displaying fares for April-2025
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range$271-$725

DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

Popular flights with American Airlines

$

  • Des Moines (DSM)to

    Myrtle Beach (MYR)
    05/21/25 - 05/28/25
    from
    $271Fare subject to changes
    Updated: 6 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    06/03/25 - 06/10/25
    from
    $271Fare subject to changes
    Updated: 6 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    05/06/25 - 05/13/25
    from
    $271Fare subject to changes
    Updated: 6 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    05/20/25 - 05/27/25
    from
    $276Fare subject to changes
    Updated: 6 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Myrtle Beach (MYR)
    05/27/25 - 06/03/25
    from
    $276Fare subject to changes
    Updated: 6 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    07/02/25 - 07/09/25
    from
    $284Fare subject to changes
    Updated: 14 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    06/10/25 - 06/17/25
    from
    $284Fare subject to changes
    Updated: 14 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    06/11/25 - 06/18/25
    from
    $284Fare subject to changes
    Updated: 14 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Myrtle Beach (MYR)
    06/24/25 - 07/01/25
    from
    $284Fare subject to changes
    Updated: 14 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    05/10/25 - 05/17/25
    from
    $284Fare subject to changes
    Updated: 6 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    07/01/25 - 07/08/25
    from
    $284Fare subject to changes
    Updated: 14 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    07/05/25 - 07/12/25
    from
    $284Fare subject to changes
    Updated: 14 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Myrtle Beach (MYR)
    06/25/25 - 07/02/25
    from
    $284Fare subject to changes
    Updated: 14 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    05/17/25 - 05/24/25
    from
    $289Fare subject to changes
    Updated: 6 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    05/03/25 - 05/10/25
    from
    $289Fare subject to changes
    Updated: 6 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    06/17/25 - 06/24/25
    from
    $297Fare subject to changes
    Updated: 14 hours ago
    Round trip
    I
    Economy

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Flights from Des Moines to Myrtle Beach with American Airlines

Find deals on Des Moines to Myrtle Beach flights

$

Des Moines (DSM)to

Myrtle Beach (MYR)
10/07/25 - 10/14/25

Round trip

I

Economy

from
$332Fare subject to changes
Updated: 15 hours ago

Des Moines (DSM)to

Myrtle Beach (MYR)
11/01/25 - 11/08/25

Round trip

I

Economy

from
$367Fare subject to changes
Updated: 5 hours ago

Des Moines (DSM)to

Myrtle Beach (MYR)
11/23/25 - 11/29/25

Round trip

I

Economy

from
$737Fare subject to changes
Updated: 15 hours ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

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