
Flights from Des Moines to Myrtle Beach with American Airlines
Recent searches for flights from Des Moines to Myrtle Beach
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Popular flights with American Airlines
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*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Find deals on Des Moines to Myrtle Beach flights
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Des Moines (DSM)to
Myrtle Beach (MYR)
10/07/25 - 10/14/25
Round trip
I
Economy
from
$332Fare subject to changes
Updated: 15 hours ago
Des Moines (DSM)to
Myrtle Beach (MYR)
11/01/25 - 11/08/25
Round trip
I
Economy
from
$367Fare subject to changes
Updated: 5 hours ago
Des Moines (DSM)to
Myrtle Beach (MYR)
11/23/25 - 11/29/25
Round trip
I
Economy
from
$737Fare subject to changes
Updated: 15 hours ago
*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.