Flights from Des Moines to Chicago with American Airlines

Recent searches for flights from Des Moines to Chicago

Apr 2025
From$194*
Updated: 2 hours ago
Round tripIEconomy
May 2025
From$189*
Updated: 2 hours ago
Round tripIEconomy
Jun 2025
From$189*
Updated: 2 hours ago
Round tripIEconomy
$189
$439
Displaying fares for April-2025
13

Su

APR

14

Mo

15

Tu

16

We

17

Th

18

Fr

19

Sa

20

Su

21

Mo

22

Tu

23

We

24

Th

25

Fr

26

Sa

27

Su

28

Mo

29

Tu

30

We

01

Th

MAY

02

Fr

03

Sa

04

Su

05

Mo

06

Tu

07

We

08

Th

09

Fr

10

Sa

11

Su

12

Mo

range$189-$439

DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

Popular flights with American Airlines

$

  • Des Moines (DSM)to

    Chicago (ORD)
    06/22/25 - 06/29/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    06/27/25 - 07/04/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    06/04/25 - 06/11/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    05/03/25 - 05/10/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Chicago (ORD)
    05/05/25 - 05/12/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    05/10/25 - 05/17/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    05/14/25 - 05/21/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    05/17/25 - 05/24/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Chicago (ORD)
    05/21/25 - 05/28/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    05/22/25 - 05/29/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    05/24/25 - 05/31/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    05/28/25 - 06/04/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Chicago (ORD)
    05/30/25 - 06/06/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    07/01/25 - 07/08/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    07/02/25 - 07/09/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Chicago (ORD)
    07/09/25 - 07/16/25
    from
    $189Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Flights from Des Moines to Chicago with American Airlines

Weather in Chicago

Saturday

few clouds

57Ā°F

04/12/25

Sunday

light rain

52Ā°F

04/13/25

Monday

overcast clouds

57Ā°F

04/14/25

Tuesday

light rain

49Ā°F

04/15/25

Wednesday

scattered clouds

50Ā°F

04/16/25

Thursday

light rain

41Ā°F

04/17/25

Friday

light rain

65Ā°F

04/18/25

Powered by: OpenWeatherMap.org

Find deals on Des Moines to Chicago flights

$

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Looking for more? See other routes.

Explore American Airlines's Top-Pick Destinations