American Airlines flights from Des Moines to Mexico

Popular flights with American Airlines

$

  • Des Moines (DSM)to

    Cancun (CUN)
    07/25/25 - 07/30/25
    from
    $506*
    Updated: 4 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    04/09/25 - 04/13/25
    from
    $562*
    Updated: 7 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    03/26/25 - 04/02/25
    from
    $592*
    Updated: 8 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    05/25/25 - 05/29/25
    from
    $593*
    Updated: 6 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Cancun (CUN)
    06/28/25 - 07/05/25
    from
    $606*
    Updated: 3 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Mexico City (MEX)
    04/23/25 - 05/09/25
    from
    $504*
    Updated: 1 hour ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cabo San Lucas (SJD)
    04/08/25 - 04/12/25
    from
    $534*
    Updated: 4 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cabo San Lucas (SJD)
    06/22/25 - 06/30/25
    from
    $570*
    Updated: 22 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Puerto Vallarta (PVR)
    05/27/25 - 06/01/25
    from
    $526*
    Updated: 22 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cozumel (CZM)
    06/18/25 - 06/25/25
    from
    $528*
    Updated: 8 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Guadalajara (GDL)
    05/17/25 - 06/08/25
    from
    $543*
    Updated: 21 hours ago
    Round trip
    I
    Economy

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

American Airlines flights from Des Moines to Mexico

Find more Des Moines to Mexico deals

$

Des Moines (DSM)to

Cancun (CUN)
05/15/25 - 05/20/25

Round trip

I

Economy

from
$475
Updated: 3 hours ago

Des Moines (DSM)to

Cabo San Lucas (SJD)
09/24/25 - 09/30/25

Round trip

I

Economy

from
$550
Updated: 20 hours ago

Des Moines (DSM)to

Puerto Vallarta (PVR)
05/27/25 - 06/01/25

Round trip

I

Economy

from
$526
Updated: 22 hours ago

Des Moines (DSM)to

Cozumel (CZM)
06/18/25 - 06/25/25

Round trip

I

Economy

from
$528
Updated: 8 hours ago

Des Moines (DSM)to

Guadalajara (GDL)
05/17/25 - 06/08/25

Round trip

I

Economy

from
$543
Updated: 21 hours ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

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